Evaluation of the MCFLIRT Correction Algorithm in Head Motion from Resting State fMRI Data
In the last few years, resting-state functional MRI (rs-fMRI) was widely used to investigate the architecture of brain networks by investigating the Blood Oxygenation Level Dependent response. This technique represented an interesting, robust and reliable approach to compare pathologic and healthy subjects in order to investigate neurodegenerative diseases evolution. On the other hand, the elaboration of rs-fMRI data resulted to be very prone to noise due to confounding factors especially the head motion. Head motion has long been known to be a source of artefacts in task-based functional MRI studies, but it has become a particularly challenging problem in recent studies using rs-fMRI. The aim of this work was to evaluate in MS patients a well-known motion correction algorithm from the FMRIB's Software Library - MCFLIRT - that could be applied to minimize the head motion distortions, allowing to correctly interpret rs-fMRI results.
 Wang, K., Liang, M., Wang, L., Tian, L., Zhang, X., Li, K., & Jiang, T. (2007). Altered functional connectivity in early Alzheimer's disease: a resting‐state fMRI study. Human brain mapping, 28(10), 967-978.
 Di Martino, A., Scheres, A., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Shehzad, Z., et al. (2008). Functional connectivity of human striatum: a resting state FMRI study. Cerebral cortex, 18(12), 2735-2747.
 Van Den Heuvel, M. P., Pol, H. E. H. (2010). Exploring the brain network: a review on resting-state fMRI functional connectivity. European neuropsychopharmacology, 20(8), 519-534.
 Van Dijk, KR, Sabuncu, M. R., & Buckner, R. L. (2012). The influence of head motion on intrinsic functional connectivity MRI. Neuroimage, 59(1), 431-438.
 Pruim, RH, Mennes, M, van Rooij, D, Llera, A, Buitelaar, J. K., & Beckmann, C. F. (2015). ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data. Neuroimage, 112, 267-277.
 Ardekani, B. A., Bachman, A. H., & Helpern, J. A. (2001). A quantitative comparison of motion detection algorithms in fMRI. Magnetic resonance imaging, 19(7), 959-963.
 Jenkinson, M., Bannister, P., Brady, J. M. and Smith, S. M. Improved Optimisation for the Robust and Accurate Linear Registration and Motion Correction of Brain Images. NeuroImage, 17(2), 825-841, 2002.
 M. Jenkinson, C.F. Beckmann, T.E. Behrens, M.W. Woolrich, S.M. Smith. FSL. NeuroImage, 62:782-90, 2012.
 Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., et al., (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of neurology, 69(2), 292-302.