International Science Index


The Effects of Three Months of HIIT on Plasma Adiponectin on Overweight College Men


Adiponectin is a cytokine secreted by the adipose tissue that functions as an anti-inflammatory, antiathrogenic and anti-diabetic substance. Its density is inversely correlated with body mass index. The purpose of this research was to examine the effect of 12 weeks of high intensity interval training (HIIT) with the level of serum adiponectin and some selected adiposity markers in overweight and fat college students. This was a clinical research in which 24 students with BMI between 25 kg/m2 to 30 kg/m2. The sample was purposefully selected and then randomly assigned into two groups of experimental (age =22.7±1.5 yr.; weight = 85.8±3.18 kg and height =178.7±3.29 cm) and control (age =23.1±1.1 yr.; weight = 79.1±2.4 kg and height =181.3±4.6 cm), respectively. The experimental group participated in an aerobic exercise program for 12 weeks, three sessions per weeks at a high intensity between 85% to 95% of maximum heart rate (considering the over load principle). Prior and after the termination of exercise protocol, the level of serum adiponectin, BMI, waist to hip ratio, and body fat percentages were calculated. The data were analyzed by using SPSS: PC 16.0 and statistical procedure such as ANCOVA, was used. The results indicated that 12 weeks of intensive interval training led to the increase of serum adiponectin level and decrease of body weight, body fat percent, body mass index and waist to hip ratio (P < 0.05). Based on the results of this research, it may be concluded that participation in intensive interval training for 12 weeks is a non-invasive treatment to increase the adiponectin level while decreasing some of the anthropometric indices associated with obesity or being overweight.

[1] J. M. Ardekani, M. A. Ardekan, H. Sedghi. “Comparison of blood levels of the hormone leptin in obese diabetic and nondiabetic patients,” J Shahid Sadoughi Yazd Univ Med Sci, 12 (2), 9-14, 2004.
[2] B. Nicklas, “Endurance exercise and adipose tissue,” Boca Raton, Florida: CRC PRESS; 2002.
[3] T. Kondo, I. Kobayashi, M. Murakami. “Effect of exercise on circulating adipokine levels in obese young women,” J Endocrinol. 53(2), 189-95, 2006.
[4] T. Kadowaki, T. Yamauchi, N. Kubota, et al. “Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome,” J Clin Invest. 116(7), 1784-92, 2006.
[5] J. J. Diez, P. Iglesias, “The role of the novel adipocyte-derived hormone adiponectin in human disease,” Eur J Endocrinol. 148, 293-300, 2003.
[6] C. Weyer, T. Funahashi, S. Tanaka, et al. “Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia,” J Clin Endocrinol Metab. 86, 1930-5, 2001.
[7] A. B. Awad, P. G. Bradford, “Adipose tissue and inflammation,” Boca Raton, Florida: CRC Press; 2010.
[8] E. Park, M. J. Shin, N. Chung, “The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients,” Nutr Res Pract. 1, 65-69, 2007.
[9] K. Hotta, T. Funahashi, Y. Arita, et al. “Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients,” Arterioscler Thromb Vasc Biol. 20(6), 1595-9, 2000.
[10] T. Yamauchi, .J Kamon, Y. Minokoshi, et al. “Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase,” Nat Med. 8, 1288-95, 2002.
[11] T. Kawano, T. Saito, T. Yasu, et al. “Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease,” Metabolism. 54, 653-6, 2005.
[12] J. C. Richards, T. K. Johnson, J. N. Kuzma, M. C. Lonac, M. M. Schweder, W. F. Voyles, “Short-term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to â-adrenergic stimulation” J Physiol. 588, 2961-72, 2010.
[13] H. Yokoyama, M. Emoto T. Araki, et al. “Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes,” Diabetes Care. 27(7), 1756-8, 2004.
[14] M. Kumada, S. Kihara, S. Sumitsuji, et al. “Association of hypoadiponectinemia with coronary artery disease in men,” Arterioscler Thromb Vasc Biol. 23(1), 85-9, 2003.
[15] A. Rashidlamir, S. Gholamian, A. Ebrahimi-Atri, M. Seyyedalhoseyni, M Hesar-Kooshki, “Effect of Regular Aerobic Exercise on Plasma Levels of Resistin and Adiponectin in Active Young Females,” J Mazand Univ Med Sci. 23(101), 73-83, 2013.
[16] M. Hemmatinafar, M. R. Kordi, S. Choopani, S. Choobineh, R. Gharari Arefi, “The Effect of High Intensity Interval Training (HIIT) on Plasma Adiponectin Levels, Insulin Sensitivity and Resistance in Sedentary Young Men,” J zanjan Univ Med Sci. 21(84), 1-12, 2013.
[17] R. R. Kraemer, V. D. Castracane, “Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin,” Exp Biol Med. 232(2), 184-94, 2007.
[18] E. G. Trapp, D. J. Chisholm, J Freund, et al. “The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women,” Int J Obes. 32(4), 684-91, 2008.
[19] M. R. Kordi, S. Choopani, M. Hemmatinafar, Z. Choopani. “The effects of the six week high intensity interval training (HIIT) on resting plasma levels of adiponectin and fat loss in sedentary young women,” Journal of Jahrom University of Medical Sciences. 11(1), 23-31, 2013.
[20] S. D. Buchan, S. T. Ollis, J. D. Young, et al. “The effects of time and intensity of exercise on novel and established markers of cvd in adolescent youth,” Am J Hum Biol. 23, 517-26, 2011.
[21] C. Platat, A. Wagner, T. Klumpp, B. Schweitzer, C. Simon, “Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents,” Diabetologia. 49, 2078-85, 2006.
[22] B. S. Metcalf, A. N Jeffery, J. Hosking, L. D. Voss, N. Sattar, T. J. Wilkin, “Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (Early Bird 38),” Diabetes care. 32, 468-73, 2009.
[23] M. Glaister, H. Hauck, C. S. Abraham, et al. “Familiarization, reliability, and comparability of a 40-m maximal shuttle run test,” J Sports Sci Med. 8(1), 77-82, 2009.
[24] P. Poirier, J. P. Després, “Exrcise in weight management of obesity,” Am J Physiol. 19(3), 459-70, 2001.
[25] K. Wynne, S. Stanley, B. McGowan, et al. “Appetite control,” J Endocrinol. 184(2), 294-318, 2005.
[26] E. S. Kim, J. A. Im, K. C. Kim, J. H. Park, S. H. Suh, Y. Jekal, et al. “Improved Insulin Sensitivity and Adiponectin Level after Exercise Training in Obese Korean Youth,” Obesity. 15, 3023-3030, 2007.
[27] Q. Zeng, L. F. u. N. Isobe, H. Ohkoshi, K. Ohmori, Y. Kawakami. “Effect of exercise on adiponectin and adiponectin receptor levels in rats,” Life Sciences. 80, 454-459, 2007.
[28] J. Jurimae, P. Purge, T. Jurimae, “Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers,” Metabolism. 55, 13-19, 2006.
[29] A. Esteghamati, O. Khalilzadeh, H. Ashraf, A. Zandieh, A. Morteza, A. Rashidi, M. Nakhjavani, “Physical activity is correlated with serum leptin independent of obesity: results of the national surveillance of risk factors of noncommunicable diseases in Iran (SuRFNCD-2007),” Metabolism. 59(12), 1730-35, 2010.
[30] E. H. Koh, J. Y. Park, H. S. Park, et al. “Essential role of mitochondrial function in adiponectin synthesis in adipocytes,” Diabetes. 56(12), 2973-81, 2007.
[31] F. Yamaner, T. Bayraktaroğlu, H. Atmaca, M. A. Ziyagil, K. Tamer, “Serum leptin, lipoprotein levels, and glucose homeostasis, between national wrestlers and sedentary males,” Turk. J Med Sci. 40(3), 471-77, 2010.
[32] B. A. Emken, J Richey, B. Belcher, Y. W. Hsu, D. Spruijt-Metz, “Objectively measured physical activity is negatively associated with plasma adiponectin levels in minority female youth,” Int J Pediatr Endocrinol. 347, 636-8, 2010.
[33] E. T. Garekania, H. Mohebbib, R. R. Kraemer, R. Fathia, “Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat,” Peptides. 32, 1008-12, 2011.