International Science Index

International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering

4
6982
Lung Nodule Detection in CT Scans
Abstract:
In this paper we describe a computer-aided diagnosis (CAD) system for automated detection of pulmonary nodules in computed-tomography (CT) images. After extracting the pulmonary parenchyma using a combination of image processing techniques, a region growing method is applied to detect nodules based on 3D geometric features. We applied the CAD system to CT scans collected in a screening program for lung cancer detection. Each scan consists of a sequence of about 300 slices stored in DICOM (Digital Imaging and Communications in Medicine) format. All malignant nodules were detected and a low false-positive detection rate was achieved.
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1122
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3
7002
Automated ECG Segmentation Using Piecewise Derivative Dynamic Time Warping
Abstract:

Electrocardiogram (ECG) segmentation is necessary to help reduce the time consuming task of manually annotating ECG's. Several algorithms have been developed to segment the ECG automatically. We first review several of such methods, and then present a new single lead segmentation method based on Adaptive piecewise constant approximation (APCA) and Piecewise derivative dynamic time warping (PDDTW). The results are tested on the QT database. We compared our results to Laguna's two lead method. Our proposed approach has a comparable mean error, but yields a slightly higher standard deviation than Laguna's method.

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1555
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2
9878
EEG-Based Fractal Analysis of Different Motor Imagery Tasks using Critical Exponent Method
Abstract:

The objective of this paper is to characterize the spontaneous Electroencephalogram (EEG) signals of four different motor imagery tasks and to show hereby a possible solution for the present binary communication between the brain and a machine ora Brain-Computer Interface (BCI). The processing technique used in this paper was the fractal analysis evaluated by the Critical Exponent Method (CEM). The EEG signal was registered in 5 healthy subjects,sampling 15 measuring channels at 1024 Hz.Each channel was preprocessed by the Laplacian space ltering so as to reduce the space blur and therefore increase the spaceresolution. The EEG of each channel was segmented and its Fractaldimension (FD) calculated. The FD was evaluated in the time interval corresponding to the motor imagery and averaged out for all the subjects (each channel). In order to characterize the FD distribution,the linear regression curves of FD over the electrodes position were applied. The differences FD between the proposed mental tasks are quantied and evaluated for each experimental subject. The obtained results of the proposed method are a substantial fractal dimension in the EEG signal of motor imagery tasks and can be considerably utilized as the multiple-states BCI applications.

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1372
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1
16891
Gene Network Analysis of PPAR-γ: A Bioinformatics Approach Using STRING
Abstract:

Gene networks present a graphical view at the level of gene activities and genetic functions and help us to understand complex interactions in a meaningful manner. In the present study, we have analyzed the gene interaction of PPAR-γ (peroxisome proliferator-activated receptor gamma) by search tool for retrieval of interacting genes. We find PPAR-γ is highly networked by genetic interactions with 10 genes: RXRA (retinoid X receptor, alpha), PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha), NCOA1 (nuclear receptor coactivator 1), NR0B2 (nuclear receptor subfamily 0, group B, member 2), HDAC3 (histone deacetylase 3), MED1 (mediator complex subunit 1), INS (insulin), NCOR2 (nuclear receptor co-repressor 2), PAX8 (paired box 8), ADIPOQ (adiponectin) and it augurs well for the fact that obesity and several other metabolic disorders are inter related.

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3719
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